Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

We developed a high-throughput HTRF (homogeneous time-resolved fluorescence) assay for Akt kinase activity and screened approx. 270000 compounds for their ability to inhibit the three isoforms of Akt. Two Akt inhibitors were identified that exhibited isoenzyme specificity. The first compound (Akt-I-...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Barnett, Stanley F., Defeo-Jones, Deborah, Fu, Sheng, Hancock, Paula J., Haskell, Kathleen M., Jones, Raymond E., Kahana, Jason A., Kral, Astrid M., Leander, Karen, Lee, Ling L., Malinowski, John, McAVOY, Elizabeth M., Nahas, Debbie D., Robinson, Ronald G., Huber, Hans E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Portland Press Ltd. 2005
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134710/
https://ncbi.nlm.nih.gov/pubmed/15456405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041140
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk