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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors
We developed a high-throughput HTRF (homogeneous time-resolved fluorescence) assay for Akt kinase activity and screened approx. 270000 compounds for their ability to inhibit the three isoforms of Akt. Two Akt inhibitors were identified that exhibited isoenzyme specificity. The first compound (Akt-I-...
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| Asıl Yazarlar: | , , , , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Portland Press Ltd.
2005
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1134710/ https://ncbi.nlm.nih.gov/pubmed/15456405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041140 |
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