Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

We developed a high-throughput HTRF (homogeneous time-resolved fluorescence) assay for Akt kinase activity and screened approx. 270000 compounds for their ability to inhibit the three isoforms of Akt. Two Akt inhibitors were identified that exhibited isoenzyme specificity. The first compound (Akt-I-...

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Hlavní autoři: Barnett, Stanley F., Defeo-Jones, Deborah, Fu, Sheng, Hancock, Paula J., Haskell, Kathleen M., Jones, Raymond E., Kahana, Jason A., Kral, Astrid M., Leander, Karen, Lee, Ling L., Malinowski, John, McAVOY, Elizabeth M., Nahas, Debbie D., Robinson, Ronald G., Huber, Hans E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2005
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134710/
https://ncbi.nlm.nih.gov/pubmed/15456405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041140
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