Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

We developed a high-throughput HTRF (homogeneous time-resolved fluorescence) assay for Akt kinase activity and screened approx. 270000 compounds for their ability to inhibit the three isoforms of Akt. Two Akt inhibitors were identified that exhibited isoenzyme specificity. The first compound (Akt-I-...

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Detalhes bibliográficos
Main Authors: Barnett, Stanley F., Defeo-Jones, Deborah, Fu, Sheng, Hancock, Paula J., Haskell, Kathleen M., Jones, Raymond E., Kahana, Jason A., Kral, Astrid M., Leander, Karen, Lee, Ling L., Malinowski, John, McAVOY, Elizabeth M., Nahas, Debbie D., Robinson, Ronald G., Huber, Hans E.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134710/
https://ncbi.nlm.nih.gov/pubmed/15456405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041140
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