The Interplay between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt

The Akt protein, a serine/threonine kinase, plays important roles in cell survival, apoptosis, and oncogenes. Akt is translocated to the plasma membrane for activation. Akt-membrane binding is mediated by direct interactions between its pleckstrin homology domain (PHD) and phosphatidylinositol 3,4,5...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Agamasu, Constance, Ghanam, Ruba H., Xu, Fei, Sun, Yong, Chen, Yabing, Saad, Jamil S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217684/
https://ncbi.nlm.nih.gov/pubmed/27872186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752816
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