TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes

BACKGROUND: The molecular determinants of clinical responses to decitabine therapy in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) are unclear. METHODS: We enrolled 84 adult patients with AML or MDS in a single-institution trial of decitabine to identify somatic muta...

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Pubblicato in:N Engl J Med
Autori principali: Welch, John S., Petti, Allegra A., Miller, Christopher A., Fronick, Catrina C., O'Laughlin, Michelle, Fulton, Robert S., Wilson, Richard K., Baty, Jack D., Duncavage, Eric J., Tandon, Bevan, Lee, Yi-Shan, Wartman, Lukas D., Uy, Geoffrey L., Ghobadi, Armin, Tomasson, Michael H., Pusic, Iskra, Romee, Rizwan, Fehniger, Todd A., Stockerl-Goldstein, Keith E., Vij, Ravi, Oh, Stephen T., Abboud, Camille N., Cashen, Amanda F., Schroeder, Mark A., Jacoby, Meagan A., Heath, Sharon E., Luber, Kierstin, Janke, Megan R., Hantel, Andrew, Khan, Niloufer, Sukhanova, Madina J., Knoebel, Randall W., Stock, Wendy, Graubert, Timothy A., Walter, Matthew J., Westervelt, Peter, Link, Daniel C., DiPersio, John F., Ley, Timothy J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217532/
https://ncbi.nlm.nih.gov/pubmed/27959731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1605949
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