Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy

Multiple system atrophy (MSA) is a fatal neurodegenerative disorder characterized by the pathological accumulation of alpha-synuclein (α-syn) in oligodendrocytes. Therapeutic efforts to stop or delay the progression of MSA have yielded suboptimal results in clinical trials, and there are no efficien...

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Bibliografske podrobnosti
izdano v:Acta Neuropathol Commun
Main Authors: Valera, Elvira, Spencer, Brian, Fields, Jerel A., Trinh, Ivy, Adame, Anthony, Mante, Michael, Rockenstein, Edward, Desplats, Paula, Masliah, Eliezer
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217191/
https://ncbi.nlm.nih.gov/pubmed/28057080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0409-1
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