PD1 blockade enhances cytotoxicity of in vitro expanded natural killer cells towards myeloma cells

Aiming for an adoptive natural killer (NK) cell therapy, we have developed a novel protocol to expand NK cells from peripheral blood. With this protocol using anti-human CD16 antibody and interleukin (IL)-2, NK (CD3(−)CD56(+)) cells could be expanded about 4000-fold with over 70% purity during a 21-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Guo, Yanan, Feng, Xiaoli, Jiang, Yang, Shi, Xiaoyun, Xing, Xiangling, Liu, Xiaoli, Li, Nailin, Fadeel, Bengt, Zheng, Chengyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217023/
https://ncbi.nlm.nih.gov/pubmed/27356741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10235
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