Polo-like kinase 1 inhibition diminishes acquired resistance to epidermal growth factor receptor inhibition in non-small cell lung cancer with T790M mutations

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are effective against non-small cell lung cancer (NSCLC) with activating EGFR mutations, but resistance is inevitable. Mechanisms of acquired resistance include T790M mutations and epithelial–mesenchymal transition (EMT). One...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Yuehong, Singh, Ratnakar, Wang, Liguang, Nilsson, Monique, Goonatilake, Ruchitha, Tong, Pan, Li, Lerong, Giri, Uma, Villalobos, Pamela, Mino, Barbara, Rodriguez-Canales, Jaime, Wistuba, Ignacio, Wang, Jing, Heymach, John V., Johnson, Faye M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216995/
https://ncbi.nlm.nih.gov/pubmed/27384992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10332
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