Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases

The heparan sulfate (HS) mimic/heparanase inhibitor roneparstat (SST0001) shows antitumor activity in preclinical sarcoma models. We hypothesized that this 100% N-acetylated and glycol-split heparin could interfere with the functions of several receptor tyrosine kinases (RTK) coexpressed in sarcomas...

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Publicat a:Oncotarget
Autors principals: Cassinelli, Giuliana, Favini, Enrica, Dal Bo, Laura, Tortoreto, Monica, De Maglie, Marcella, Dagrada, Gianpaolo, Pilotti, Silvana, Zunino, Franco, Zaffaroni, Nadia, Lanzi, Cinzia
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216983/
https://ncbi.nlm.nih.gov/pubmed/27374103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10292
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