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Overactive IGF1/Insulin Receptors and NRASQ61R Mutation Drive Mechanisms of Resistance to Pazopanib and Define Rational Combination Strategies to Treat Synovial Sarcoma

Pazopanib is approved for treatment of advanced soft tissue sarcomas, but primary and secondary drug resistance limits its clinical utility. We investigated the molecular mechanisms mediating pazopanib resistance in human synovial sarcoma (SS) models. We found reduced cell sensitivity to pazopanib a...

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Detalles Bibliográficos
Publicado en:Cancers (Basel)
Main Authors: Lanzi, Cinzia, Dal Bo, Laura, Favini, Enrica, Tortoreto, Monica, Beretta, Giovanni Luca, Arrighetti, Noemi, Zaffaroni, Nadia, Cassinelli, Giuliana
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468361/
https://ncbi.nlm.nih.gov/pubmed/30909453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11030408
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