Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy of rapalogs for treating hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Although recent studies facilitate the identification of crucial genes and relevant regulatory pathways, therapeutic approaches against advanced HCC are insufficiently effective. Therefore, we aimed here to develop potent th...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Watari, Kosuke, Nishitani, Ayumi, Shibata, Tomohiro, Noda, Masaki, Kawahara, Akihiko, Akiba, Jun, Murakami, Yuichi, Yano, Hirohisa, Kuwano, Michihiko, Ono, Mayumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216950/
https://ncbi.nlm.nih.gov/pubmed/27329724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10161
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