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β-cell insulin receptor deficiency during in utero development induces an islet compensatory overgrowth response
The presence of insulin receptor (IR) on β-cells suggests that insulin has an autocrine/paracrine role in the regulation of β-cell function. It has previously been reported that the β-cell specific loss of IR (βIRKO) leads to the development of impaired glycemic regulation and β-cell death in mice....
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| Publicado en: | Oncotarget |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5216695/ https://ncbi.nlm.nih.gov/pubmed/27384998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10342 |
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