Antiviral Efficacy and Host Immune Response Induction during Sequential Treatment with SB 9200 Followed by Entecavir in Woodchucks

SB 9200, an orally bioavailable dinucleotide, activates the viral sensor proteins, retinoic acid-inducible gene 1 (RIG-I) and nucleotide-binding oligomerization domain-containing protein 2 (NOD2) causing the induction of the interferon (IFN) signaling cascade for antiviral defense. The present study...

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Publicat a:PLoS One
Autors principals: Suresh, Manasa, Korolowicz, Kyle E., Balarezo, Maria, Iyer, Radhakrishnan P., Padmanabhan, Seetharamaiyer, Cleary, Dillon, Gimi, Rayomand, Sheri, Anjaneyulu, Yon, Changsuek, Kallakury, Bhaskar V., Tucker, Robin D., Afdhal, Nezam, Menne, Stephan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215947/
https://ncbi.nlm.nih.gov/pubmed/28056062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169631
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