Antiviral Efficacy and Host Innate Immunity Associated with SB 9200 Treatment in the Woodchuck Model of Chronic Hepatitis B

SB 9200, an oral prodrug of the dinucleotide SB 9000, is being developed for the treatment of chronic hepatitis B virus (HBV) infection and represents a novel class of antivirals. SB 9200 is thought to activate the viral sensor proteins, retinoic acid-inducible gene 1 (RIG-I) and nucleotide-binding...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Korolowicz, Kyle E., Iyer, Radhakrishnan P., Czerwinski, Stefanie, Suresh, Manasa, Yang, Junming, Padmanabhan, Seetharamaiyer, Sheri, Anjaneyulu, Pandey, Rajendra K., Skell, Jeffrey, Marquis, Judith K., Kallakury, Bhaskar V., Tucker, Robin D., Menne, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995001/
https://ncbi.nlm.nih.gov/pubmed/27552102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161313
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