HDAC and Proteasome Inhibitors Synergize to Activate Pro-Apoptotic Factors in Synovial Sarcoma

Conventional cytotoxic therapies for synovial sarcoma provide limited benefit, and no drugs specifically targeting its driving SS18-SSX fusion oncoprotein are currently available. Patients remain at high risk for early and late metastasis. A high-throughput drug screen consisting of over 900 tool co...

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Veröffentlicht in:PLoS One
Hauptverfasser: Laporte, Aimée N., Barrott, Jared J., Yao, Ren Jie, Poulin, Neal M., Brodin, Bertha A., Jones, Kevin B., Underhill, T. Michael, Nielsen, Torsten O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215898/
https://ncbi.nlm.nih.gov/pubmed/28056055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169407
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