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Synovial sarcoma: recent discoveries as a roadmap to new avenues for therapy
Oncogenesis in synovial sarcoma is driven by the chromosomal translocation t(X,18; p11,q11), which generates an in-frame fusion of the SWI/SNF subunit SS18 to the C-terminal repression domains of SSX1 or SSX2. Proteomic studies have identified an integral role of SS18-SSX in the SWI/SNF complex, and...
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| 發表在: | Cancer Discov |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4320664/ https://ncbi.nlm.nih.gov/pubmed/25614489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1246 |
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