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Synovial sarcoma: recent discoveries as a roadmap to new avenues for therapy

Oncogenesis in synovial sarcoma is driven by the chromosomal translocation t(X,18; p11,q11), which generates an in-frame fusion of the SWI/SNF subunit SS18 to the C-terminal repression domains of SSX1 or SSX2. Proteomic studies have identified an integral role of SS18-SSX in the SWI/SNF complex, and...

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Bibliografiske detaljer
Udgivet i:Cancer Discov
Main Authors: Nielsen, Torsten O., Poulin, Neal M., Ladanyi, Marc
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320664/
https://ncbi.nlm.nih.gov/pubmed/25614489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1246
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