Identification of cytotoxic agents disrupting synovial sarcoma oncoprotein interactions by proximity ligation assay

Conventional cytotoxic therapies for synovial sarcoma provide limited benefit. Drugs specifically targeting the product of its driver translocation are currently unavailable, in part because the SS18-SSX oncoprotein functions via aberrant interactions within multiprotein complexes. Proximity ligatio...

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Udgivet i:Oncotarget
Main Authors: Laporte, Aimée N., Ji, Jennifer X., Ma, Limin, Nielsen, Torsten O., Brodin, Bertha A.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085163/
https://ncbi.nlm.nih.gov/pubmed/27120803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8882
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