Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model

Zika virus (ZIKV) is currently undergoing pandemic emergence. While disease is typically subclinical, severe neurologic manifestations in fetuses and newborns after congenital infection underscore an urgent need for antiviral interventions. The adenosine analog BCX4430 has broad-spectrum activity ag...

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Veröffentlicht in:Antiviral Res
Hauptverfasser: Julander, Justin G., Siddharthan, Venkatraman, Evans, Joe, Taylor, Ray, Tolbert, Kelsey, Apuli, Chad, Stewart, Jason, Collins, Preston, Gebre, Makda, Neilson, Skot, Van Wettere, Arnaud, Lee, Young-Min, Sheridan, William P., Morrey, John D., Babu, Y.S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215849/
https://ncbi.nlm.nih.gov/pubmed/27838352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2016.11.003
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