BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening infections from highly pathogenic viruses, such as the Ebola virus. Cellular kinases phosphorylate BCX4430 to a triphosphate that mimics ATP; viral RNA poly...

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Bibliografiske detaljer
Udgivet i:J Infect Public Health
Main Authors: Taylor, Raymond, Kotian, Pravin, Warren, Travis, Panchal, Rekha, Bavari, Sina, Julander, Justin, Dobo, Sylvia, Rose, Angela, El-Kattan, Yahya, Taubenheim, Brian, Babu, Yarlagadda, Sheridan, William P.
Format: Artigo
Sprog:Inglês
Udgivet: King Saud Bin Abdulaziz University for Health Sciences. Production and hosting by Elsevier Limited. 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937725/
https://ncbi.nlm.nih.gov/pubmed/27095300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jiph.2016.04.002
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