Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model

Zika virus (ZIKV) is currently undergoing pandemic emergence. While disease is typically subclinical, severe neurologic manifestations in fetuses and newborns after congenital infection underscore an urgent need for antiviral interventions. The adenosine analog BCX4430 has broad-spectrum activity ag...

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Détails bibliographiques
Publié dans:Antiviral Res
Auteurs principaux: Julander, Justin G., Siddharthan, Venkatraman, Evans, Joe, Taylor, Ray, Tolbert, Kelsey, Apuli, Chad, Stewart, Jason, Collins, Preston, Gebre, Makda, Neilson, Skot, Van Wettere, Arnaud, Lee, Young-Min, Sheridan, William P., Morrey, John D., Babu, Y.S.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215849/
https://ncbi.nlm.nih.gov/pubmed/27838352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2016.11.003
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