The SCF(β-TRCP) E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

The SCF(β-TRCP) E3 ubiquitin ligase complex plays pivotal roles in normal cellular physiology and in pathophysiological conditions. Identification of β-transducin repeat-containing protein (β-TRCP) substrates is therefore critical to understand SCF(β-TRCP) biology and function. Here, we used a β-TRC...

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Publicado no:Sci Signal
Main Authors: Shimizu, Kouhei, Fukushima, Hidefumi, Ogura, Kohei, Lien, Evan C., Nihira, Naoe Taira, Zhang, Jinfang, North, Brian J., Guo, Ailan, Nagashima, Katsuyuki, Nakagawa, Tadashi, Hoshikawa, Seria, Watahiki, Asami, Okabe, Koji, Yamada, Aya, Toker, Alex, Asara, John M., Fukumoto, Satoshi, Nakayama, Keiichi I., Nakayama, Keiko, Inuzuka, Hiroyuki, Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215841/
https://ncbi.nlm.nih.gov/pubmed/28049764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aah4117
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