A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase

[Image: see text] The general secretion (Sec) pathway is a conserved essential pathway in bacteria and is the primary route of protein export across the cytoplasmic membrane. During protein export, the signal peptidase LepB catalyzes the cleavage of the signal peptide and subsequent release of matur...

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Veröffentlicht in:ACS Infect Dis
Hauptverfasser: Bonnett, Shilah A., Ollinger, Juliane, Chandrasekera, Susantha, Florio, Stephanie, O’Malley, Theresa, Files, Megan, Jee, Jo-Ann, Ahn, James, Casey, Allen, Ovechkina, Yulia, Roberts, David, Korkegian, Aaron, Parish, Tanya
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2016
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215716/
https://ncbi.nlm.nih.gov/pubmed/27642770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00075
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