A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase

[Image: see text] The general secretion (Sec) pathway is a conserved essential pathway in bacteria and is the primary route of protein export across the cytoplasmic membrane. During protein export, the signal peptidase LepB catalyzes the cleavage of the signal peptide and subsequent release of matur...

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Bibliografische gegevens
Gepubliceerd in:ACS Infect Dis
Hoofdauteurs: Bonnett, Shilah A., Ollinger, Juliane, Chandrasekera, Susantha, Florio, Stephanie, O’Malley, Theresa, Files, Megan, Jee, Jo-Ann, Ahn, James, Casey, Allen, Ovechkina, Yulia, Roberts, David, Korkegian, Aaron, Parish, Tanya
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2016
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215716/
https://ncbi.nlm.nih.gov/pubmed/27642770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00075
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