A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase

[Image: see text] The general secretion (Sec) pathway is a conserved essential pathway in bacteria and is the primary route of protein export across the cytoplasmic membrane. During protein export, the signal peptidase LepB catalyzes the cleavage of the signal peptide and subsequent release of matur...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Bonnett, Shilah A., Ollinger, Juliane, Chandrasekera, Susantha, Florio, Stephanie, O’Malley, Theresa, Files, Megan, Jee, Jo-Ann, Ahn, James, Casey, Allen, Ovechkina, Yulia, Roberts, David, Korkegian, Aaron, Parish, Tanya
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215716/
https://ncbi.nlm.nih.gov/pubmed/27642770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00075
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