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Inhibition of the Sole Type I Signal Peptidase of Mycobacterium tuberculosis Is Bactericidal under Replicating and Nonreplicating Conditions

Proteins secreted by bacteria perform functions vital for cell survival and play a role in virulence in Mycobacterium tuberculosis. M. tuberculosis lepB (Rv2903c) encodes the sole homolog of the type I signal peptidase (SPase). The lepB gene is essential in M. tuberculosis, since we could delete the...

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Bibliografski detalji
Glavni autori: Ollinger, J., O'Malley, T., Ahn, J., Odingo, J., Parish, T.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347204/
https://ncbi.nlm.nih.gov/pubmed/22427625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00224-12
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