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A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling

Middle T antigen (MT), the principal oncoprotein of murine polyomavirus, transforms by association with cellular proteins. Protein phosphatase 2A (PP2A), YAP, Src family tyrosine kinases, Shc, phosphatidylinositol 3-kinase (PI3K), and phospholipase C-γ1 (PLCγ1) have all been implicated in MT transfo...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Denis, Deborah, Rouleau, Cecile, Schaffhausen, Brian S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215327/
https://ncbi.nlm.nih.gov/pubmed/27852846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01774-16
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