Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP

Murine polyomavirus has repeatedly provided insights into tumorigenesis, revealing key control mechanisms such as tyrosine phosphorylation and phosphoinositide 3-kinase (PI3K) signaling. We recently demonstrated that polyomavirus small T antigen (ST) binds YAP, a major effector of Hippo signaling, t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Virol
Prif Awduron: Rouleau, Cecile, Pores Fernando, Arun T., Hwang, Justin H., Faure, Nathalie, Jiang, Tao, White, Elizabeth A., Roberts, Thomas M., Schaffhausen, Brian S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2016
Pynciau:
Transformation and Oncogenesis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984622/
https://ncbi.nlm.nih.gov/pubmed/27194756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00417-16
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg