Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP

Murine polyomavirus has repeatedly provided insights into tumorigenesis, revealing key control mechanisms such as tyrosine phosphorylation and phosphoinositide 3-kinase (PI3K) signaling. We recently demonstrated that polyomavirus small T antigen (ST) binds YAP, a major effector of Hippo signaling, t...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Rouleau, Cecile, Pores Fernando, Arun T., Hwang, Justin H., Faure, Nathalie, Jiang, Tao, White, Elizabeth A., Roberts, Thomas M., Schaffhausen, Brian S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
Materias:
Transformation and Oncogenesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984622/
https://ncbi.nlm.nih.gov/pubmed/27194756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00417-16
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