Characterization of [(11)C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain

PURPOSE: [(11)C]Lu AE92686 is a positron emission tomography (PET) radioligand that has recently been validated for examining phosphodiesterase 10A (PDE10A) in the human striatum. [(11)C]Lu AE92686 has high affinity for PDE10A (IC (50) = 0.39 nM) and may also be suitable for examination of the subst...

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Vydáno v:Eur J Nucl Med Mol Imaging
Hlavní autoři: Yang, Kai-Chun, Stepanov, Vladimir, Amini, Nahid, Martinsson, Stefan, Takano, Akihiro, Nielsen, Jacob, Bundgaard, Christoffer, Bang-Andersen, Benny, Grimwood, Sarah, Halldin, Christer, Farde, Lars, Finnema, Sjoerd J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2016
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215309/
https://ncbi.nlm.nih.gov/pubmed/27817159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-016-3544-9
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