Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates

BACKGROUND: Positron emission tomography microdosing of radiolabeled drugs allows for noninvasive studies of organ exposure in vivo. The aim of the present study was to examine and compare the brain exposure of 12 commercially available CNS drugs and one non-CNS drug. METHODS: The drugs were radiola...

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Detalhes bibliográficos
Publicado no:Int J Neuropsychopharmacol
Main Authors: Schou, Magnus, Varnäs, Katarina, Lundquist, Stefan, Nakao, Ryuji, Amini, Nahid, Takano, Akihiro, Finnema, Sjoerd J., Halldin, Christer, Farde, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648157/
https://ncbi.nlm.nih.gov/pubmed/25813017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyv036
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