Human embryonic stem cells do not change their X-inactivation status during differentiation

Applications of ESCs require faithful chromatin changes during differentiation but the fate of each X-chromosome-state in differentiating ESCs is unclear. Female human ESC-lines either carry two active X-chromosomes (XaXa), an Xa and inactive-X-chromosome with or without XIST-RNA-coating (Xi(XIST+)X...

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Publicado en:Cell Rep
Autores principales: Patel, Sanjeet, Bonora, Giancarlo, Sahakyan, Anna, Kim, Rachel, Chronis, Constantinos, Langerman, Justin, Fitz-Gibbon, Sorel, Rubbi, Liudmilla, Skelton, Rhys J.P., Ardehali, Reza, Pellegrini, Matteo, Lowry, William E., Clark, Amander T., Plath, Kathrin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214931/
https://ncbi.nlm.nih.gov/pubmed/27989715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.054
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