Human naïve pluripotent stem cells model X-chromosome dampening and X-inactivation

Naïve human embryonic stem cells (hESCs) can be derived from primed hESCs or directly from blastocysts, but their X-chromosome state has remained unresolved. Here, we show that the inactive X-chromosome (X(i)) of primed hESCs was reactivated in naïve culture conditions. Like cells of the blastocyst,...

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Bibliographic Details
Published in:Cell Stem Cell
Main Authors: Sahakyan, Anna, Kim, Rachel, Chronis, Constantinos, Sabri, Shan, Bonora, Giancarlo, Theunissen, Thorold W., Kuoy, Edward, Langerman, Justin, Clark, Amander T., Jaenisch, Rudolf, Plath, Kathrin
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5218861/
https://ncbi.nlm.nih.gov/pubmed/27989770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.10.006
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