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Human naïve pluripotent stem cells model X-chromosome dampening and X-inactivation
Naïve human embryonic stem cells (hESCs) can be derived from primed hESCs or directly from blastocysts, but their X-chromosome state has remained unresolved. Here, we show that the inactive X-chromosome (X(i)) of primed hESCs was reactivated in naïve culture conditions. Like cells of the blastocyst,...
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| 出版年: | Cell Stem Cell |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5218861/ https://ncbi.nlm.nih.gov/pubmed/27989770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.10.006 |
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