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Human naïve pluripotent stem cells model X-chromosome dampening and X-inactivation

Naïve human embryonic stem cells (hESCs) can be derived from primed hESCs or directly from blastocysts, but their X-chromosome state has remained unresolved. Here, we show that the inactive X-chromosome (X(i)) of primed hESCs was reactivated in naïve culture conditions. Like cells of the blastocyst,...

詳細記述

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書誌詳細
出版年:Cell Stem Cell
主要な著者: Sahakyan, Anna, Kim, Rachel, Chronis, Constantinos, Sabri, Shan, Bonora, Giancarlo, Theunissen, Thorold W., Kuoy, Edward, Langerman, Justin, Clark, Amander T., Jaenisch, Rudolf, Plath, Kathrin
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5218861/
https://ncbi.nlm.nih.gov/pubmed/27989770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.10.006
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