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Long-range chromatin contacts in embryonic stem cells reveal a role for pluripotency factors and Polycomb proteins in genome organization

The relationship between three-dimensional organization of the genome and gene-regulatory networks is poorly understood. Here, we examined long-range chromatin interactions genome-wide in embryonic stem cells (ESCs), iPSCs, and fibroblasts, and uncover a pluripotency-specific genome organization tha...

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Huvudupphovsmän: Denholtz, Matthew, Bonora, Giancarlo, Chronis, Constantinos, Splinter, Erik, de Laat, Wouter, Ernst, Jason, Pellegrini, Matteo, Plath, Kathrin
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3825755/
https://ncbi.nlm.nih.gov/pubmed/24035354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.08.013
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