Betulin suppressed interleukin-1β-induced gene expression, secretion and proteolytic activity of matrix metalloproteinase in cultured articular chondrocytes and production of matrix metalloproteinase in the knee joint of rat

We investigated whether betulin affects the gene expression, secretion and proteolytic activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3 in the rat knee joint to evaluate the potential chondroprotective effect of...

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Publicado en:Korean J Physiol Pharmacol
Main Authors: Ra, Ho Jong, Lee, Hyun Jae, Jo, Ho Seung, Nam, Dae Cheol, Lee, Young Bok, Kang, Byeong Hun, Moon, Dong Kyu, Kim, Dong Hee, Lee, Choong Jae, Hwang, Sun-Chul
Formato: Artigo
Idioma:Inglês
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214907/
https://ncbi.nlm.nih.gov/pubmed/28066137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2017.21.1.19
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