Structural Basis of Alcohol Inhibition of the Pentameric Ligand-gated Ion Channel ELIC

The structural basis for alcohol modulation of neuronal pentameric ligand-gated ion channels (pLGICs) remains elusive. We determined an inhibitory mechanism of alcohol on the pLGIC Erwinia chrysanthemi (ELIC) through direct binding to the pore. X-ray structures of ELIC co-crystallized with 2-bromoet...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Structure
Egile Nagusiak: Chen, Qiang, Wells, Marta M., Tillman, Tommy S., Kinde, Monica N., Cohen, Aina, Xu, Yan, Tang, Pei
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214846/
https://ncbi.nlm.nih.gov/pubmed/27916519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.11.007
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