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Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

Soluble oligomers of amyloid β-protein (oAβ) isolated from the brains of Alzheimer's disease (AD) patients have been shown experimentally (in the absence of amyloid plaques) to impair hippocampal synaptic plasticity, decrease synapses, induce tau hyperphosphorylation and neuritic dystrophy, act...

詳細記述

保存先:
書誌詳細
出版年:J Neurosci
主要な著者: Yang, Ting, Li, Shaomin, Xu, Huixin, Walsh, Dominic M., Selkoe, Dennis J.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214627/
https://ncbi.nlm.nih.gov/pubmed/28053038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1698-16.2016
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