Bound water molecules and conformational stabilization help mediate an antigen-antibody association.

We report the three-dimensional structures, at 1.8-A resolution, of the Fv fragment of the anti-hen egg white lysozyme antibody D1.3 in its free and antigen-bound forms. These structures reveal a role for solvent molecules in stabilizing the complex and provide a molecular basis for understanding th...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Bhat, T N, Bentley, G A, Boulot, G, Greene, M I, Tello, D, Dall'Acqua, W, Souchon, H, Schwarz, F P, Mariuzza, R A, Poljak, R J
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1994
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521459/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8302837/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.3.1089
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