Bound water molecules and conformational stabilization help mediate an antigen-antibody association.

We report the three-dimensional structures, at 1.8-A resolution, of the Fv fragment of the anti-hen egg white lysozyme antibody D1.3 in its free and antigen-bound forms. These structures reveal a role for solvent molecules in stabilizing the complex and provide a molecular basis for understanding th...

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Main Authors: Bhat, T N, Bentley, G A, Boulot, G, Greene, M I, Tello, D, Dall'Acqua, W, Souchon, H, Schwarz, F P, Mariuzza, R A, Poljak, R J
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC521459/
https://ncbi.nlm.nih.gov/pubmed/8302837
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