Humanization of murine monoclonal antibodies through variable domain resurfacing.

Two murine monoclonal antibodies, N901 (anti-CD56) and anti-B4 (anti-CD19), were humanized by a process we call "resurfacing." A systematic analysis of known antibody structures has been used to determine the relative solvent accessibility distributions of amino acid residues in murine and human ant...

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Detaylı Bibliyografya
Yayımlandı:	Proc Natl Acad Sci U S A
Asıl Yazarlar:	Roguska, M A, Pedersen, J T, Keddy, C A, Henry, A H, Searle, S J, Lambert, J M, Goldmacher, V S, Blättler, W A, Rees, A R, Guild, B C
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	National Academy of Sciences 1994
Konular:	Research Article
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521435/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8302875/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.3.969
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Humanization of murine monoclonal antibodies through variable domain resurfacing.

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