Humanization of murine monoclonal antibodies through variable domain resurfacing.

Two murine monoclonal antibodies, N901 (anti-CD56) and anti-B4 (anti-CD19), were humanized by a process we call "resurfacing." A systematic analysis of known antibody structures has been used to determine the relative solvent accessibility distributions of amino acid residues in murine and human ant...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Roguska, M A, Pedersen, J T, Keddy, C A, Henry, A H, Searle, S J, Lambert, J M, Goldmacher, V S, Blättler, W A, Rees, A R, Guild, B C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521435/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8302875/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.3.969
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!