Humanization of murine monoclonal antibodies through variable domain resurfacing.

Two murine monoclonal antibodies, N901 (anti-CD56) and anti-B4 (anti-CD19), were humanized by a process we call "resurfacing." A systematic analysis of known antibody structures has been used to determine the relative solvent accessibility distributions of amino acid residues in murine and...

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Autors principals: Roguska, M A, Pedersen, J T, Keddy, C A, Henry, A H, Searle, S J, Lambert, J M, Goldmacher, V S, Blättler, W A, Rees, A R, Guild, B C
Format: Artigo
Idioma:Inglês
Publicat: 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC521435/
https://ncbi.nlm.nih.gov/pubmed/8302875
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