Humanization of murine monoclonal antibodies through variable domain resurfacing.

Two murine monoclonal antibodies, N901 (anti-CD56) and anti-B4 (anti-CD19), were humanized by a process we call "resurfacing." A systematic analysis of known antibody structures has been used to determine the relative solvent accessibility distributions of amino acid residues in murine and human ant...

詳細記述

書誌詳細

出版年:	Proc Natl Acad Sci U S A
主要な著者:	Roguska, M A, Pedersen, J T, Keddy, C A, Henry, A H, Searle, S J, Lambert, J M, Goldmacher, V S, Blättler, W A, Rees, A R, Guild, B C
フォーマット:	Artigo
言語:	Inglês
出版事項:	National Academy of Sciences 1994
主題:	Research Article
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521435/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8302875/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.3.969
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!