The pattern of hMENA isoforms is regulated by TGF-β1 in pancreatic cancer and may predict patient outcome

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease in need of prognostic markers to address therapeutic choices. We have previously shown that alternative splicing of the actin regulator, hMENA, generates hMENA(11a), and hMENAΔv6 isoforms with opposite roles in cell invasion. We examin...

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Vydáno v:Oncoimmunology
Hlavní autoři: Melchionna, Roberta, Iapicca, Pierluigi, Di Modugno, Francesca, Trono, Paola, Sperduti, Isabella, Fassan, Matteo, Cataldo, Ivana, Rusev, Borislav C., Lawlor, Rita T., Diodoro, Maria Grazia, Milella, Michele, Grazi, Gian Luca, Bissell, Mina J., Scarpa, Aldo, Nisticò, Paola
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5213039/
https://ncbi.nlm.nih.gov/pubmed/28123868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1221556
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