The pattern of hMENA isoforms is regulated by TGF-β1 in pancreatic cancer and may predict patient outcome

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease in need of prognostic markers to address therapeutic choices. We have previously shown that alternative splicing of the actin regulator, hMENA, generates hMENA(11a), and hMENAΔv6 isoforms with opposite roles in cell invasion. We examin...

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Dettagli Bibliografici
Pubblicato in:Oncoimmunology
Autori principali: Melchionna, Roberta, Iapicca, Pierluigi, Di Modugno, Francesca, Trono, Paola, Sperduti, Isabella, Fassan, Matteo, Cataldo, Ivana, Rusev, Borislav C., Lawlor, Rita T., Diodoro, Maria Grazia, Milella, Michele, Grazi, Gian Luca, Bissell, Mina J., Scarpa, Aldo, Nisticò, Paola
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2016
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5213039/
https://ncbi.nlm.nih.gov/pubmed/28123868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1221556
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