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MutS inhibits RecA-mediated strand exchange with platinated DNA substrates
Human cell lines and Escherichia coli dam mutants are sensitive to the cytotoxic action of the anticancer agent, cisplatin. Introduction of mutations disabling DNA mismatch repair into these cell lines renders them resistant to the action of this drug. We used RecA-mediated strand exchange between h...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2004
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC521133/ https://ncbi.nlm.nih.gov/pubmed/15375217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406104101 |
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