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MutS inhibits RecA-mediated strand transfer with methylated DNA substrates
DNA mismatch repair (MMR) sensitizes human and Escherichia coli dam cells to the cytotoxic action of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) while abrogation of such repair results in drug resistance. In DNA methylated by MNNG, MMR action is the result of MutS recognition of O(6)-methylguanine b...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1157099/ https://ncbi.nlm.nih.gov/pubmed/15972855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki673 |
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