A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-γ activation

Loss of function of Bruton's tyrosine kinase (Btk) causes X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency in mice (xid). By using MS analysis and phosphopeptide-specific antibodies, we identified a tyrosine phosphorylation site (Y617) near the carboxyl terminus of the...

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Bibliographische Detailangaben
Hauptverfasser: Guo, Shuling, Ferl, Gregory Z., Deora, Rajendar, Riedinger, Mireille, Yin, Sheng, Kerwin, James L., Loo, Joseph A., Witte, Owen N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2004
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC521099/
https://ncbi.nlm.nih.gov/pubmed/15375214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405878101
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