A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-γ activation

Loss of function of Bruton's tyrosine kinase (Btk) causes X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency in mice (xid). By using MS analysis and phosphopeptide-specific antibodies, we identified a tyrosine phosphorylation site (Y617) near the carboxyl terminus of the...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Guo, Shuling, Ferl, Gregory Z., Deora, Rajendar, Riedinger, Mireille, Yin, Sheng, Kerwin, James L., Loo, Joseph A., Witte, Owen N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521099/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15375214/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0405878101
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