Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway

BACKGROUND: COX-2, an inducible enzyme, is associated with inflammatory diseases and carcinogenesis. Overexpression of COX-2 occurs in many human malignancies, including osteosarcoma. COX-2 positivity is form 67 to 92% in osteosarcoma, and COX-2 expresses 141-fold more in cancer stem cell spheres th...

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Detalhes bibliográficos
Publicado no:Cancer Cell Int
Main Authors: Liu, Bing, Yan, Shigui, Qu, Liyan, Zhu, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209942/
https://ncbi.nlm.nih.gov/pubmed/28053596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-016-0378-2
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