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Detecting very low allele fraction variants using targeted DNA sequencing and a novel molecular barcode-aware variant caller
BACKGROUND: Detection of DNA mutations at very low allele fractions with high accuracy will significantly improve the effectiveness of precision medicine for cancer patients. To achieve this goal through next generation sequencing, researchers need a detection method that 1) captures rare mutation-c...
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| Udgivet i: | BMC Genomics |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5209917/ https://ncbi.nlm.nih.gov/pubmed/28049435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-3425-4 |
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