Detecting very low allele fraction variants using targeted DNA sequencing and a novel molecular barcode-aware variant caller

BACKGROUND: Detection of DNA mutations at very low allele fractions with high accuracy will significantly improve the effectiveness of precision medicine for cancer patients. To achieve this goal through next generation sequencing, researchers need a detection method that 1) captures rare mutation-c...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:BMC Genomics
Egile Nagusiak: Xu, Chang, Nezami Ranjbar, Mohammad R., Wu, Zhong, DiCarlo, John, Wang, Yexun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2017
Gaiak:
Methodology Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209917/
https://ncbi.nlm.nih.gov/pubmed/28049435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-3425-4
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