smCounter2: an accurate low-frequency variant caller for targeted sequencing data with unique molecular identifiers

MOTIVATION: Low-frequency DNA mutations are often confounded with technical artifacts from sample preparation and sequencing. With unique molecular identifiers (UMIs), most of the sequencing errors can be corrected. However, errors before UMI tagging, such as DNA polymerase errors during end repair...

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Vydáno v:Bioinformatics
Hlavní autoři: Xu, Chang, Gu, Xiujing, Padmanabhan, Raghavendra, Wu, Zhong, Peng, Quan, DiCarlo, John, Wang, Yexun
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Original Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477992/
https://ncbi.nlm.nih.gov/pubmed/30192920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty790
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