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Topological transformations in proteins: effects of heating and proximity of an interface

Using a structure-based coarse-grained model of proteins, we study the mechanism of unfolding of knotted proteins through heating. We find that the dominant mechanisms of unfolding depend on the temperature applied and are generally distinct from those identified for folding at its optimal temperatu...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Zhao, Yani, Chwastyk, Mateusz, Cieplak, Marek
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209716/
https://ncbi.nlm.nih.gov/pubmed/28051124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39851
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