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Topological transformations in proteins: effects of heating and proximity of an interface
Using a structure-based coarse-grained model of proteins, we study the mechanism of unfolding of knotted proteins through heating. We find that the dominant mechanisms of unfolding depend on the temperature applied and are generally distinct from those identified for folding at its optimal temperatu...
Shranjeno v:
| izdano v: | Sci Rep |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5209716/ https://ncbi.nlm.nih.gov/pubmed/28051124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39851 |
| Oznake: |
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