Preclinical Pharmacokinetics and Biodistribution Studies of (89)Zr-Labeled Pembrolizumab

Pembrolizumab is a humanized monoclonal antibody targeting programmed cell death protein 1 (PD-1) found on T and pro-B cells. Pembrolizumab prevents PD-1 ligation by both PD-L1 and PD-L2, preventing the immune dysregulation that otherwise occurs when T-cells encounter cells expressing these ligands....

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Опубликовано в: :J Nucl Med
Главные авторы: England, Christopher G., Ehlerding, Emily B., Hernandez, Reinier, Rekoske, Brian T., Graves, Stephen A., Sun, Haiyan, Liu, Glenn, McNeel, Douglas G., Barnhart, Todd E., Cai, Weibo
Формат: Artigo
Язык:Inglês
Опубликовано: Society of Nuclear Medicine 2017
Предметы:
Novel Imaging Probes
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209640/
https://ncbi.nlm.nih.gov/pubmed/27493273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.116.177857
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